Electrospinning/Electrospray
Nitric oxide-modified linear poly(ethylenimine) fibers and uses therefor ..us.patent
| United States Patent Application | 20040131753 |
| Kind Code | A1 |
| Smith, Daniel J. ; et al. | July 8, 2004 |
Nitric oxide-modified linear poly(ethylenimine) fibers and uses therefor
A novel coating for medical devices provides nitric oxide delivery using nanofibers of linear poly(ethylenimine)diazeniumdiolate. Linear poly(ethylenimine)diazeniumdiolate releases nitric oxide (NO) in a controlled manner to tissues and organs to aid the healing process and to prevent injury to tissues at risk of injury. Electrospun nano-fibers of linear poly(ethylenimine) diazeniumdiolate deliver therapeutic levels of NO to the tissues surrounding a medical device while minimizing the alteration of the properties of the device. A nanofiber coating, because of the small size and large surface area per unit mass of the nanofibers, provides a much larger surface area per unit mass while minimizing changes in other properties of the device.
| Inventors: | Smith, Daniel J.; (Stow, OH) ; Reneker, Darrell H.; (Akron, OH) |
| Correspondence Name and Address: | George W. Moxon II, Esq. |
| Assignee Name and Adress: | The University of Akron |
| Serial No.: | 738582 |
| Series Code: | 10 |
| Filed: | December 16, 2003 |
| U.S. Current Class: | 427/2.1 |
| U.S. Class at Publication: | 427/002.1 |
| Intern'l Class: | A61L 002/00 |